Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development

Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically been centered on the study of RAG1/2 recombinases and a set...

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Publicado no:iScience
Main Authors: Chu, S. Haihua, Chabon, Jonathan R., Matovina, Chloe N., Minehart, Janna C., Chen, Bo-Ruei, Zhang, Jian, Kumar, Vipul, Xiong, Yijun, Callen, Elsa, Hung, Putzer J., Feng, Zhaohui, Koche, Richard P., Liu, X. Shirley, Chaudhuri, Jayanta, Nussenzweig, Andre, Sleckman, Barry P., Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066224/
https://ncbi.nlm.nih.gov/pubmed/32169821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100941
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