The E3 ubiquitin ligase APC/C(C) (dh1) degrades MCPH1 after MCPH1‐βTrCP2‐Cdc25A‐mediated mitotic entry to ensure neurogenesis

Mutations of microcephalin (MCPH1) can cause the neurodevelopmental disorder primary microcephaly type 1. We previously showed that MCPH1 deletion in neural stem cells results in early mitotic entry that distracts cell division mode, leading to exhaustion of the progenitor pool. Here, we show that M...

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Bibliographic Details
Published in:EMBO J
Main Authors: Liu, Xiaoqian, Zong, Wen, Li, Tangliang, Wang, Yujun, Xu, Xingzhi, Zhou, Zhong‐Wei, Wang, Zhao‐Qi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730889/
https://ncbi.nlm.nih.gov/pubmed/29150431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694443
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