Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients

The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise mechanism involved remains elusive. The molecular chaperone heat‐shock protein 90 (Hsp90) is an essential component of the cellular homeostatic mach...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Woodford, Mark R, Sager, Rebecca A, Marris, Elijah, Dunn, Diana M, Blanden, Adam R, Murphy, Ryan L, Rensing, Nicholas, Shapiro, Oleg, Panaretou, Barry, Prodromou, Chrisostomos, Loh, Stewart N, Gutmann, David H, Bourboulia, Dimitra, Bratslavsky, Gennady, Wong, Michael, Mollapour, Mehdi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730846/
https://ncbi.nlm.nih.gov/pubmed/29127155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796700
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia