Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential

Strong viral enhancers in gammaretrovirus vectors have caused cellular proto-oncogene activation and leukemia, necessitating the use of cellular promoters in “enhancerless” self-inactivating integrating vectors. However, cellular promoters result in relatively low transgene expression, often leading...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Goodman, Michael Aaron, Arumugam, Paritha, Pillis, Devin Marie, Loberg, Anastacia, Nasimuzzaman, Mohammed, Lynn, Danielle, van der Loo, Johannes Christiaan Maria, Dexheimer, Phillip Joseph, Keddache, Mehdi, Bauer, Thomas Roy, Hickstein, Dennis Durand, Russell, David William, Malik, Punam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730768/
https://ncbi.nlm.nih.gov/pubmed/29046446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01639-17
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