Mechanism of Reduction in Titers From Lentivirus Vectors Carrying Large Inserts in the 3′LTR

Self-inactivating (SIN) lentiviruses flanked by the 1.2-kb chicken hypersensitive site-4 (cHS4) insulator element provide consistent, improved expression of transgenes, but have significantly lower titers. The mechanism by which this occurs is unknown. Lengthening the lentiviral (LV) vector transgen...

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Detalhes bibliográficos
Main Authors: Urbinati, Fabrizia, Arumugam, Paritha, Higashimoto, Tomoyasu, Perumbeti, Anil, Mitts, Kyle, Xia, Ping, Malik, Punam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835256/
https://ncbi.nlm.nih.gov/pubmed/19384292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.89
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