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Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations

Allosteric autoinhibition exists in many transcription factors. The ERG proteins exhibit autoinhibition on DNA binding by the C-terminal and N-terminal inhibitory domains (CID and NID). However, the autoinhibition mechanism and allosteric pathway of ERG are unknown. In this study we intend to elucid...

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Foilsithe in:J Chem Inf Model
Main Authors: Ye, Wei, Qian, Tianle, Liu, Hao, Luo, Ray, Chen, Hai-Feng
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730271/
https://ncbi.nlm.nih.gov/pubmed/28425706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.7b00073
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