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Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited
The Ets-Related Gene (ERG) belongs to the Ets family of transcription factors and is critically important for maintenance of the hematopoietic stem cell population. A chromosomal translocation observed in the majority of human prostate cancers leads to the aberrant overexpression of ERG. We have ide...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746864/ https://ncbi.nlm.nih.gov/pubmed/23898196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301726110 |
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