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Synergistic Allosteric Mechanism of FBP and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis
Pyruvate kinase M2 (PKM2) plays a key role in tumor metabolism and regulates the rate-limiting final step of glycolysis. In tumor cells, there are two allosteric effectors of fructose-1,6-bisphosphate (FBP) and serine for PKM2. However, the relationship between FBP and serine for allosteric regulati...
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| Pubblicato in: | J Chem Inf Model |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5115163/ https://ncbi.nlm.nih.gov/pubmed/27227511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00115 |
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