Parkin Regulates the Activity of Pyruvate Kinase M2

Parkin, a ubiquitin E3 ligase, is mutated in most cases of autosomal recessive early onset Parkinson disease. It was discovered that Parkin is also mutated in glioblastoma and other human malignancies and that it inhibits tumor cell growth. Here, we identified pyruvate kinase M2 (PKM2) as a unique s...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Liu, Kun, Li, Fanzhou, Han, Haichao, Chen, Yue, Mao, Zebin, Luo, Jianyuan, Zhao, Yingming, Zheng, Bin, Gu, Wei, Zhao, Wenhui
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858978/
https://ncbi.nlm.nih.gov/pubmed/26975375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.703066
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