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Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinase M2 (PKM2) activates mTORC1 signaling through phosphorylating mTORC1 inhibitor AKT1 substr...
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| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753445/ https://ncbi.nlm.nih.gov/pubmed/26876154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21524 |
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