Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1

In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinase M2 (PKM2) activates mTORC1 signaling through phosphorylating mTORC1 inhibitor AKT1 substr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: He, Chang-Liang, Bian, Yang-Yang, Xue, Yu, Liu, Ze-Xian, Zhou, Kai-Qiang, Yao, Cui-Fang, Lin, Yan, Zou, Han-Fa, Luo, Fang-Xiu, Qu, Yuan-Yuan, Zhao, Jian-Yuan, Ye, Ming-Liang, Zhao, Shi-Min, Xu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753445/
https://ncbi.nlm.nih.gov/pubmed/26876154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21524
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