Structural and dynamics evidence for scaffold asymmetric flexibility of the human transthyretin tetramer

The molecular symmetry of multimeric proteins is generally determined by using X-ray diffraction techniques, so that the basic question as to whether this symmetry is perfectly preserved for the same protein in solution remains open. In this work, human transthyretin (TTR), a homotetrameric plasma t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zanotti, Giuseppe, Vallese, Francesca, Ferrari, Alberto, Menozzi, Ilaria, Saldaño, Tadeo E., Berto, Paola, Fernandez-Alberti, Sebastian, Berni, Rodolfo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730205/
https://ncbi.nlm.nih.gov/pubmed/29240759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187716
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