Amyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSES

Human transthyretin (TTR) is an amyloidogenic protein whose mild amyloidogenicity is enhanced by many point mutations affecting considerably the amyloid disease phenotype. To ascertain whether the high amyloidogenic potential of TTR variants may be explained on the basis of the conformational change...

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Bibliographische Detailangaben
Hauptverfasser: Cendron, Laura, Trovato, Antonio, Seno, Flavio, Folli, Claudia, Alfieri, Beatrice, Zanotti, Giuseppe, Berni, Rodolfo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757985/
https://ncbi.nlm.nih.gov/pubmed/19602727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017657
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