Amyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSES

Human transthyretin (TTR) is an amyloidogenic protein whose mild amyloidogenicity is enhanced by many point mutations affecting considerably the amyloid disease phenotype. To ascertain whether the high amyloidogenic potential of TTR variants may be explained on the basis of the conformational change...

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Détails bibliographiques
Auteurs principaux: Cendron, Laura, Trovato, Antonio, Seno, Flavio, Folli, Claudia, Alfieri, Beatrice, Zanotti, Giuseppe, Berni, Rodolfo
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757985/
https://ncbi.nlm.nih.gov/pubmed/19602727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017657
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