Amyloidogenic Potential of Transthyretin Variants: INSIGHTS FROM STRUCTURAL AND COMPUTATIONAL ANALYSES

Human transthyretin (TTR) is an amyloidogenic protein whose mild amyloidogenicity is enhanced by many point mutations affecting considerably the amyloid disease phenotype. To ascertain whether the high amyloidogenic potential of TTR variants may be explained on the basis of the conformational change...

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Main Authors: Cendron, Laura, Trovato, Antonio, Seno, Flavio, Folli, Claudia, Alfieri, Beatrice, Zanotti, Giuseppe, Berni, Rodolfo
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757985/
https://ncbi.nlm.nih.gov/pubmed/19602727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.017657
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