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Evaluating the effect of mutations and ligand binding on transthyretin homotetramer dynamics
Native transthyretin (TTR) homotetramer dissociation is the first step of the fibrils formation process in amyloid disease. A large number of specific point mutations that destabilize TTR quaternary structure have shown pro-amyloidogenic effects. Besides, several compounds have been proposed as drug...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509292/ https://ncbi.nlm.nih.gov/pubmed/28704493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181019 |
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