Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Energetic nutrients are oxidized to sustain high intra-cellular NADPH/NADP(+) ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleot...

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Udgivet i:Cell Rep
Main Authors: Prigge, Justin R., Coppo, Lucia, Martin, Sebastin S., Ogata, Fernando, Miller, Colin G., Bruschwein, Michael D., Orlicky, David J., Shearn, Colin T., Kundert, Jean A., Lytchier, Julia, Herr, Alix E., Mattsson, Åse, Taylor, Matthew P., Gustafsson, Tomas N., Arnér, Elias S.J., Holmgren, Arne, Schmidt, Edward E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730093/
https://ncbi.nlm.nih.gov/pubmed/28658624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.019
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