Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Energetic nutrients are oxidized to sustain high intra-cellular NADPH/NADP(+) ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleot...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Prigge, Justin R., Coppo, Lucia, Martin, Sebastin S., Ogata, Fernando, Miller, Colin G., Bruschwein, Michael D., Orlicky, David J., Shearn, Colin T., Kundert, Jean A., Lytchier, Julia, Herr, Alix E., Mattsson, Åse, Taylor, Matthew P., Gustafsson, Tomas N., Arnér, Elias S.J., Holmgren, Arne, Schmidt, Edward E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730093/
https://ncbi.nlm.nih.gov/pubmed/28658624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.019
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