The anti-cancer drug Sunitinib promotes autophagy and protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

Despite the success of antiretroviral therapies to control systemic HIV-1 infection, the prevalence of HIV-associated neurocognitive disorders (HAND) has not decreased among aging patients with HIV. Autophagy pathway alterations, triggered by HIV-1 proteins including gp120, Tat, and Nef, might contr...

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Pubblicato in:J Neurovirol
Autori principali: Fields, Jerel A., Metcalf, Jeff, Overk, Cassia, Adame, Anthony, Spencer, Brian, Wrasidlo, Wolfgang, Florio, Jazmin, Rockenstein, Edward, He, Johnny J., Masliah, Eliezer
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729903/
https://ncbi.nlm.nih.gov/pubmed/28105557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-016-0502-z
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