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Blockade of CD7 expression in T cells for effective chimeric antigen receptor targeting of T-cell malignancies
Effective immunotherapies for T-cell malignancies are lacking. We devised a novel approach based on chimeric antigen receptor (CAR)–redirected T lymphocytes. We selected CD7 as a target because of its consistent expression in T-cell acute lymphoblastic leukemia (T-ALL), including the most aggressive...
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| 出版年: | Blood Adv |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729624/ https://ncbi.nlm.nih.gov/pubmed/29296885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017009928 |
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