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A novel method to generate T-cell receptor–deficient chimeric antigen receptor T cells

Practical methods are needed to increase the applicability and efficacy of chimeric antigen receptor (CAR) T-cell therapies. Using donor-derived CAR-T cells is attractive, but expression of endogenous T-cell receptors (TCRs) carries the risk for graft-versus-host-disease (GVHD). To remove surface TC...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Kamiya, Takahiro, Wong, Desmond, Png, Yi Tian, Campana, Dario
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851418/
https://ncbi.nlm.nih.gov/pubmed/29507075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012823
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