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A novel method to generate T-cell receptor–deficient chimeric antigen receptor T cells
Practical methods are needed to increase the applicability and efficacy of chimeric antigen receptor (CAR) T-cell therapies. Using donor-derived CAR-T cells is attractive, but expression of endogenous T-cell receptors (TCRs) carries the risk for graft-versus-host-disease (GVHD). To remove surface TC...
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| Publicado en: | Blood Adv |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851418/ https://ncbi.nlm.nih.gov/pubmed/29507075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017012823 |
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