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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors

Selective inhibitors for each serine/threonine phosphatase (PPP) are essential to investigate the biological actions of PPPs and to guide drug development. Biologically diverse organisms (e.g., cyanobacteria, dinoflagellates, beetles) produce structurally distinct toxins that are catalytic inhibitor...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Choy, Meng S., Swingle, Mark, D’Arcy, Brandon, Abney, Kevin, Rusin, Scott F., Kettenbach, Arminja N., Page, Rebecca, Honkanen, Richard E., Peti, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5729109/
https://ncbi.nlm.nih.gov/pubmed/29156132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09368
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