Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence

Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma, suggesting that durable control of resistance will be a challenge. By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of over 20 i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Singleton, Katherine R., Crawford, Lorin, Tsui, Elizabeth, Manchester, Haley E., Maertens, Ophelia, Liu, Xiaojing, Liberti, Maria V., Magpusao, Anniefer N., Stein, Elizabeth M., Tingley, Jennifer P., Frederick, Dennie T., Boland, Genevieve M., Flaherty, Keith T., McCall, Shannon J., Krepler, Clemens, Sproesser, Katrin, Herlyn, Meenhard, Adams, Drew J., Locasale, Jason W., Cichowski, Karen, Mukherjee, Sayan, Wood, Kris C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728698/
https://ncbi.nlm.nih.gov/pubmed/29212027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.022
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