Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence

Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma, suggesting that durable control of resistance will be a challenge. By combining statistical modeling of genomic data from matched pre-treatment and post-relapse patient tumors with functional interrogation of over 20 i...

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Publicado no:Cell Rep
Main Authors: Singleton, Katherine R., Crawford, Lorin, Tsui, Elizabeth, Manchester, Haley E., Maertens, Ophelia, Liu, Xiaojing, Liberti, Maria V., Magpusao, Anniefer N., Stein, Elizabeth M., Tingley, Jennifer P., Frederick, Dennie T., Boland, Genevieve M., Flaherty, Keith T., McCall, Shannon J., Krepler, Clemens, Sproesser, Katrin, Herlyn, Meenhard, Adams, Drew J., Locasale, Jason W., Cichowski, Karen, Mukherjee, Sayan, Wood, Kris C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728698/
https://ncbi.nlm.nih.gov/pubmed/29212027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.022
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