The output of protein-coding genes shifts to circular RNAs when the pre-mRNA processing machinery is limiting

Many eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown how the ratio of linear to circular RNA is controlled or modulated. Using RNAi screening in Drosophila cells, we identify many core spliceosome and transcription termination factors that control the RNA outputs...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Liang, Dongming, Tatomer, Deirdre C., Luo, Zheng, Wu, Huang, Yang, Li, Chen, Ling-Ling, Cherry, Sara, Wilusz, Jeremy E.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728686/
https://ncbi.nlm.nih.gov/pubmed/29174924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.034
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