The output of protein-coding genes shifts to circular RNAs when the pre-mRNA processing machinery is limiting

Many eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown how the ratio of linear to circular RNA is controlled or modulated. Using RNAi screening in Drosophila cells, we identify many core spliceosome and transcription termination factors that control the RNA outputs...

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Udgivet i:Mol Cell
Main Authors: Liang, Dongming, Tatomer, Deirdre C., Luo, Zheng, Wu, Huang, Yang, Li, Chen, Ling-Ling, Cherry, Sara, Wilusz, Jeremy E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728686/
https://ncbi.nlm.nih.gov/pubmed/29174924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.034
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