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The output of protein-coding genes shifts to circular RNAs when the pre-mRNA processing machinery is limiting
Many eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown how the ratio of linear to circular RNA is controlled or modulated. Using RNAi screening in Drosophila cells, we identify many core spliceosome and transcription termination factors that control the RNA outputs...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728686/ https://ncbi.nlm.nih.gov/pubmed/29174924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.034 |
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