The GCN2-ATF4 signaling pathway activates 4E-BP to bias mRNA translation and boost antimicrobial peptide synthesis in response to bacterial infection

Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulat...

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Vydáno v:Cell Rep
Hlavní autoři: Vasudevan, Deepika, Clark, Nicholas K., Sam, Jessica, Cotham, Victoria C., Ueberheide, Beatrix, Marr, Michael T., Ryoo, Hyung Don
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728446/
https://ncbi.nlm.nih.gov/pubmed/29166596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.096
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