The GCN2-ATF4 signaling pathway activates 4E-BP to bias mRNA translation and boost antimicrobial peptide synthesis in response to bacterial infection

Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulat...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Vasudevan, Deepika, Clark, Nicholas K., Sam, Jessica, Cotham, Victoria C., Ueberheide, Beatrix, Marr, Michael T., Ryoo, Hyung Don
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728446/
https://ncbi.nlm.nih.gov/pubmed/29166596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.096
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