A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2

Erythroid progenitors are the largest consumers of iron in the human body. In these cells, a high flux of iron must reach the mitochondrial matrix to form sufficient heme to support hemoglobinization. Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endo...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Khalil, Shadi, Holy, Maja, Grado, Stephen, Fleming, Robert, Kurita, Ryo, Nakamura, Yukio, Goldfarb, Adam
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728310/
https://ncbi.nlm.nih.gov/pubmed/29296759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003772
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