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The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment

Hypoxia is an aspect of the tumor microenvironment that is linked to radiation and chemotherapy resistance, metastasis, and poor prognosis. The ability of hypoxic tumor cells to achieve these cancer hallmarks is, in part, due to changes in their gene expression profiles. Cancer cells have a high dem...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Melanson, Gaelan, Timpano, Sara, Uniacke, James
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727761/
https://ncbi.nlm.nih.gov/pubmed/29317983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/6098107
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