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Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation

Translation initiation is a focal point of translational control and requires the binding of eIF4E to the 5′ cap of mRNA. Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homolog of eIF4E, eIF4E2. T...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Timpano, Sara, Uniacke, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865923/
https://ncbi.nlm.nih.gov/pubmed/27002144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717363
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