In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

RNA regulatory elements (RREs) are an important yet relatively under-explored facet of gene regulation. Deciphering the prevalence and functional impact of this post-transcriptional control layer requires technologies for disrupting RREs without perturbing cellular homeostasis. Here we describe geno...

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Udgivet i:Nat Commun
Main Authors: Wu, Qianxin, Ferry, Quentin R. V., Baeumler, Toni A., Michaels, Yale S., Vitsios, Dimitrios M., Habib, Omer, Arnold, Roland, Jiang, Xiaowei, Maio, Stefano, Steinkraus, Bruno R., Tapia, Marta, Piazza, Paolo, Xu, Ni, Holländer, Georg A., Milne, Thomas A., Kim, Jin-Soo, Enright, Anton J., Bassett, Andrew R., Fulga, Tudor A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727397/
https://ncbi.nlm.nih.gov/pubmed/29235467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00686-2
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