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Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs
CRISPR-based transcription regulators (CRISPR-TRs) have transformed the current synthetic biology landscape by allowing specific activation or repression of any target gene. Here we report a modular and versatile framework enabling rapid implementation of inducible CRISPR-TRs in mammalian cells. Thi...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339017/ https://ncbi.nlm.nih.gov/pubmed/28256578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14633 |
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