Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs

Small RNAs target invaders for silencing in the CRISPR-Cas pathways that protect bacteria and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence elements acquired from invaders that guide CRISPR-associated (Cas) proteins back to the complementary invading DNA or RNA. Here,...

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Autori principali: Hale, Caryn R., Majumdar, Sonali, Elmore, Joshua, Pfister, Neil, Compton, Mark, Olson, Sara, Resch, Alissa M., Glover, Claiborne V. C., Graveley, Brenton R., Terns, Rebecca M., Terns, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278580/
https://ncbi.nlm.nih.gov/pubmed/22227116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.10.023
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