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CTCF driven TERRA transcription facilitates completion of telomere DNA replication

Telomere repeat DNA forms a nucleo-protein structure that can obstruct chromosomal DNA replication, especially under conditions of replication stress. Transcription of telomere repeats can initiate at subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (TERRA), but the role of t...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Beishline, Kate, Vladimirova, Olga, Tutton, Stephen, Wang, Zhuo, Deng, Zhong, Lieberman, Paul M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727389/
https://ncbi.nlm.nih.gov/pubmed/29235471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02212-w
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