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Fibrinolysis Shutdown Is Associated with a Five-Fold Increase in Mortality in Trauma Patients Lacking Hypersensitivity to Tissue Plasminogen Activator
BACKGROUND: Fibrinolysis shutdown(SD) is an independent risk factor for increased mortality in trauma. High levels of plasminogen activator inhibitor-1(PAI-1) directly binding tissue plasminogen activator(tPA) is a proposed mechanism for SD, however patients with low PAI-1 levels present to the hosp...
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| Опубликовано в: : | J Trauma Acute Care Surg |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726780/ https://ncbi.nlm.nih.gov/pubmed/29190254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001718 |
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