Fibrinolysis Shutdown Is Associated with a Five-Fold Increase in Mortality in Trauma Patients Lacking Hypersensitivity to Tissue Plasminogen Activator

BACKGROUND: Fibrinolysis shutdown(SD) is an independent risk factor for increased mortality in trauma. High levels of plasminogen activator inhibitor-1(PAI-1) directly binding tissue plasminogen activator(tPA) is a proposed mechanism for SD, however patients with low PAI-1 levels present to the hosp...

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Publicat a:J Trauma Acute Care Surg
Autors principals: Moore, Hunter B, Moore, Ernest E, Huebner, Benjamin R, Dzieciatkowska, Monika, Stettler, Gregory R, Nunns, Geoffrey R, Lawson, Peter J, Ghasabyan, Arsen, Chandler, James, Banerjee, Anirban, Silliman, Christopher, Sauaia, Angela, Hansen, Kirk C
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726780/
https://ncbi.nlm.nih.gov/pubmed/29190254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001718
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