Fibrinolysis Shutdown Is Associated with a Five-Fold Increase in Mortality in Trauma Patients Lacking Hypersensitivity to Tissue Plasminogen Activator

BACKGROUND: Fibrinolysis shutdown(SD) is an independent risk factor for increased mortality in trauma. High levels of plasminogen activator inhibitor-1(PAI-1) directly binding tissue plasminogen activator(tPA) is a proposed mechanism for SD, however patients with low PAI-1 levels present to the hosp...

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Vydáno v:J Trauma Acute Care Surg
Hlavní autoři: Moore, Hunter B, Moore, Ernest E, Huebner, Benjamin R, Dzieciatkowska, Monika, Stettler, Gregory R, Nunns, Geoffrey R, Lawson, Peter J, Ghasabyan, Arsen, Chandler, James, Banerjee, Anirban, Silliman, Christopher, Sauaia, Angela, Hansen, Kirk C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726780/
https://ncbi.nlm.nih.gov/pubmed/29190254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001718
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