Fibrinolysis Shutdown Is Associated with a Five-Fold Increase in Mortality in Trauma Patients Lacking Hypersensitivity to Tissue Plasminogen Activator

BACKGROUND: Fibrinolysis shutdown(SD) is an independent risk factor for increased mortality in trauma. High levels of plasminogen activator inhibitor-1(PAI-1) directly binding tissue plasminogen activator(tPA) is a proposed mechanism for SD, however patients with low PAI-1 levels present to the hosp...

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Detalhes bibliográficos
Publicado no:J Trauma Acute Care Surg
Main Authors: Moore, Hunter B, Moore, Ernest E, Huebner, Benjamin R, Dzieciatkowska, Monika, Stettler, Gregory R, Nunns, Geoffrey R, Lawson, Peter J, Ghasabyan, Arsen, Chandler, James, Banerjee, Anirban, Silliman, Christopher, Sauaia, Angela, Hansen, Kirk C
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726780/
https://ncbi.nlm.nih.gov/pubmed/29190254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001718
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