Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin

BACKGROUND: A subset of trauma patients undergo fibrinolysis shutdown rather than pathologic hyperfibrinolysis, contributing to organ failure. The molecular basis for fibrinolysis shutdown in trauma is incompletely understood. Elastase released from primed/activated human neutrophils (HNE) has histo...

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I publikationen:J Trauma Acute Care Surg
Huvudupphovsmän: Barrett, Christopher D., Moore, Hunter B., Banerjee, Anirban, Silliman, Christopher C., Moore, Ernest E., Yaffe, Michael B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767103/
https://ncbi.nlm.nih.gov/pubmed/28837538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001685
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