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Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells

Numerous groups have documented that Ascorbic Acid (AA) promotes cardiomyocyte differentiation from both mouse and human ESCs and iPSCs. AA is now considered indispensable for the routine production of hPSC-cardiomyocytes (CMs) using defined media; however, the mechanisms involved with the inductive...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Perino, Maria Grazia, Yamanaka, Satoshi, Riordon, Daniel R., Tarasova, Yelena, Boheler, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726630/
https://ncbi.nlm.nih.gov/pubmed/29232368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188569
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