The PI3K pathway in human disease

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, resulting in regulatory approval of one isoform-selectiv...

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Bibliografiska uppgifter
I publikationen:Cell
Huvudupphovsmän: Fruman, David A., Chiu, Honyin, Hopkins, Benjamin D., Bagrodia, Shubha, Cantley, Lewis C., Abraham, Robert T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726441/
https://ncbi.nlm.nih.gov/pubmed/28802037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.029
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