Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

BACKGROUND: Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have shown that salidroside can exert protective effects against hypoxia-induced pu...

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Dettagli Bibliografici
Pubblicato in:BMC Pulm Med
Autori principali: Gui, Di, Cui, Zhimin, Zhang, Lin, Yu, Chang, Yao, Dan, Xu, Min, Chen, Mayun, Wu, Peiliang, Li, Guoping, Wang, Liangxing, Huang, Xiaoying
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726034/
https://ncbi.nlm.nih.gov/pubmed/29233105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-017-0477-4
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