Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway

BACKGROUND: Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have shown that salidroside can exert protective effects against hypoxia-induced pu...

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Bibliographische Detailangaben
Veröffentlicht in:BMC Pulm Med
Hauptverfasser: Gui, Di, Cui, Zhimin, Zhang, Lin, Yu, Chang, Yao, Dan, Xu, Min, Chen, Mayun, Wu, Peiliang, Li, Guoping, Wang, Liangxing, Huang, Xiaoying
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726034/
https://ncbi.nlm.nih.gov/pubmed/29233105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-017-0477-4
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