Engineering PTEN-L for Cell-Mediated Delivery

The tumor suppressor PTEN is frequently inactivated in glioblastoma. PTEN-L is a long form of PTEN produced by translation from an alternate upstream start codon. Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken u...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Lavictoire, Sylvie J., Gont, Alexander, Julian, Lisa M., Stanford, William L., Vlasschaert, Caitlyn, Gray, Douglas A., Jomaa, Danny, Lorimer, Ian A.J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725211/
https://ncbi.nlm.nih.gov/pubmed/29255742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.11.006
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