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Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals

Ubiquitin specific protease 4 (USP4) is a highly networked deubiquitinating enzyme with reported roles in cancer, innate immunity and RNA splicing. In mammals it has two dominant isoforms arising from inclusion or skipping of exon 7 (E(7)). We evaluated two plausible mechanisms for the generation of...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Vlasschaert, Caitlyn, Xia, Xuhua, Gray, Douglas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4735762/
https://ncbi.nlm.nih.gov/pubmed/26833277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20039
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