A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis

Neoplastic cells display reprogrammed metabolism due to the heightened energetic demands and the need for biomass synthesis of a growing tumor. Targeting metabolic vulnerabilities is thus an important goal for cancer therapy. Here, we describe a novel small-molecule arylsulfonamide (N-cyclobutyl-N-(...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Dai, Xin, Kaluz, Stefan, Jiang, Ying, Shi, Lei, Mckinley, DeAngelo, Wang, Yingzhe, Wang, Binghe, Van Meir, Erwin G., Tan, Chalet
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
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Priority Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725089/
https://ncbi.nlm.nih.gov/pubmed/29245898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22104
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