A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis

Neoplastic cells display reprogrammed metabolism due to the heightened energetic demands and the need for biomass synthesis of a growing tumor. Targeting metabolic vulnerabilities is thus an important goal for cancer therapy. Here, we describe a novel small-molecule arylsulfonamide (N-cyclobutyl-N-(...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Dai, Xin, Kaluz, Stefan, Jiang, Ying, Shi, Lei, Mckinley, DeAngelo, Wang, Yingzhe, Wang, Binghe, Van Meir, Erwin G., Tan, Chalet
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725089/
https://ncbi.nlm.nih.gov/pubmed/29245898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22104
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky