A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies

A valid preclinical tumor model should recapitulate the tumor microenvironment. Immune and stromal components are absent in immunodeficient models of pancreatic cancer. While these components are present in genetically engineered models such as Kras(G12D); Trp53(R172H); Pdx-1Cre (KPC), immense varia...

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Vydáno v:J Gastrointest Surg
Hlavní autoři: Majumder, Kaustav, Arora, Nivedita, Modi, Shrey, Chugh, Rohit, Nomura, Alice, Giri, Bhuwan, Dawra, Rajinder, Ramakrishnan, Sundaram, Banerjee, Sulagna, Saluja, Ashok, Dudeja, Vikas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724755/
https://ncbi.nlm.nih.gov/pubmed/26582596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11605-015-2985-y
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