A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies

A valid preclinical tumor model should recapitulate the tumor microenvironment. Immune and stromal components are absent in immunodeficient models of pancreatic cancer. While these components are present in genetically engineered models such as Kras(G12D); Trp53(R172H); Pdx-1Cre (KPC), immense varia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Gastrointest Surg
Prif Awduron: Majumder, Kaustav, Arora, Nivedita, Modi, Shrey, Chugh, Rohit, Nomura, Alice, Giri, Bhuwan, Dawra, Rajinder, Ramakrishnan, Sundaram, Banerjee, Sulagna, Saluja, Ashok, Dudeja, Vikas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724755/
https://ncbi.nlm.nih.gov/pubmed/26582596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11605-015-2985-y
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