Minnelide Overcomes Oxaliplatin Resistance by Downregulating DNA Repair Pathway in Pancreatic Cancer

INTRODUCTION: Oxaliplatin is part of pancreatic cancer therapy in FOLFIRINOX or GEMOX/XELOX regimen. DNA damage repair is one of the factors responsible for oxaliplatin resistance that eventually develops in this cancer. Triptolide/Minnelide has been shown to be effective against pancreatic cancer i...

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Vydáno v:J Gastrointest Surg
Hlavní autoři: Modi, Shrey, Kir, Devika, Giri, Bhuwan, Majumder, Kaustav, Arora, Nivedita, Dudeja, Vikas, Banerjee, Sulagna, Saluja, Ashok K
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698020/
https://ncbi.nlm.nih.gov/pubmed/26503259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11605-015-3000-3
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