Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

Cancer immunotherapy has emerged as a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who have cancer. A key factor that limits therapeutic success is the infiltration of tumors by cells of the myeloid lineage. The inhibitory recept...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ring, Nan Guo, Herndler-Brandstetter, Dietmar, Weiskopf, Kipp, Shan, Liang, Volkmer, Jens-Peter, George, Benson M., Lietzenmayer, Melanie, McKenna, Kelly M., Naik, Tejaswitha J., McCarty, Aaron, Zheng, Yunjiang, Ring, Aaron M., Flavell, Richard A., Weissman, Irving L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724266/
https://ncbi.nlm.nih.gov/pubmed/29158380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710877114
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