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High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing

The CRISPR/Cas9 prokaryotic adaptive immune system and its swift repurposing for genome editing enables modification of any prespecified genomic sequence with unprecedented accuracy and efficiency, including targeted gene repair. We used the CRISPR/Cas9 system for targeted repair of patient-specific...

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Bibliografski detalji
Izdano u:Mol Ther Nucleic Acids
Glavni autori: Sürün, Duran, Schwäble, Joachim, Tomasovic, Ana, Ehling, Roy, Stein, Stefan, Kurrle, Nina, von Melchner, Harald, Schnütgen, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723376/
https://ncbi.nlm.nih.gov/pubmed/29499925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.11.001
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