WNK1/HSN2 kinase inhibition ameliorates neuropathic pain by reducing maladaptive KCC2 inhibitory phosphorylation and restoring GABA inhibition

WNK1/HSN2 kinase, mutated in a Mendelian form of congenital pain insensitivity, contributes to a maladaptive decrease in KCC2 cotransporter activity and a loss of GABA inhibition in the spared nerve injury (SNI) model of neuropathic pain by increasing KCC2 inhibitory phosphorylation at Thr906/Thr100...

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Publicado no:Sci Signal
Main Authors: Kahle, Kristopher T., Schmouth, Jean-François, Lavastre, Valérie, Latremoliere, Alban, Zhang, Jinwei, Andrews, Nick, Laganière, Janet, Rochefort, Daniel, Hince, Pascale, Castonguay, Geneviève, Gaudet, Rébecca, Mapplebeck, Josiane C.S., Sotocinal, Susana G., Duan, JingJing, Ward, Catherine, Khanna, Arjun R., Mogil, Jeffrey S., Dion, Patrick A., Woolf, Clifford J., Inquimbert, Perrine, Rouleau, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723157/
https://ncbi.nlm.nih.gov/pubmed/27025876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad0163
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