GABA(A) receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl(−)-sensitive WNK1 kinase

The K(+)–Cl(−) co-transporter KCC2 (SLC12A5) tunes the efficacy of GABA(A) receptor-mediated transmission by regulating the intraneuronal chloride concentration [Cl(−)](i). KCC2 undergoes activity-dependent regulation in both physiological and pathological conditions. The regulation of KCC2 by synap...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Heubl, Martin, Zhang, Jinwei, Pressey, Jessica C., Al Awabdh, Sana, Renner, Marianne, Gomez-Castro, Ferran, Moutkine, Imane, Eugène, Emmanuel, Russeau, Marion, Kahle, Kristopher T., Poncer, Jean Christophe, Lévi, Sabine
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701213/
https://ncbi.nlm.nih.gov/pubmed/29176664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01749-0
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